Description
Human SIRP beta/CD172b Recombinant Protein Fc Tag Lyophilized has been recombinantly produced in HEK293 cells.
Signal-regulatory protein beta-1 (SIRP beta 1) also known as SIRPbeta1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. SIRPbeta1 is a transmembrane protein that has three Ig-like domains in its extracellular region and a short cytoplasmic tail. Human SIRPbeta1 is expressed on monocytes and granulocytes but not on lymphocytes. SIRP beta 1 contains short cytoplasmic domains that lack cytoplasmic sequence motifs capable of recruiting SHP-2 and SHP-1. In addition, they contain a single basic lysine residue within the hydrophobic transmembrane domain.
This protein carries a human IgG1 Fc Tag at the C-terminal. The protein has a calculated MW of 63.7 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation