Description
Introduction: TIE1 is an angiopoitein receptor which takes part in hematopoiesis,angiogenesis and vasculogenesis.TIE1 is expressed primarily on endothelial and hematopoietic progenitor cells. TIE1 is expressed in immature hematopoietic Recombinant Human TIE1 protein cells and platelets. TIE1 upregulates the cell adhesion molecules(CAMs) VCAM-1,ICAM-1 and E-selectinthrough a p38-dependent mechanism. TIE1 has a proinflammatory effect and takes part in the endothelial inflammatory diseases such as atherosclerosis.
Description: TIE1 Human Recombinant produced in HEK293 Cells is a single, glycosylated polypeptide chain containing 977 amino acids (22-759 a.a) and having a molecular mass of 106.8kDa. TIE1 is fused to a 239 amino acid hIgG-His-Tag at C-terminus and is purified by proprietary chromatographic techniques