Description
Interleukin IL-1beta also known as catabolin, is a member of the interleukin 1 cytokine family. IL1B, the cytokine encoded by the IL1B gene, is an inflammatory response and fever mediator, and contributes to several lymphocyte activities including growth and differentiation of B-cells, proliferation of T-helper Type2 (Th2) clones, and activation of Th17 cells. IL-1beta is produced in peripheral blood mononuclear cells, tissue macrophages, and dendritic fine cells in response to immune responses, inflammation, infection, and trauma cells such as cytium. IL1B is required for T-cell activation in some immune responses, and thus could contribute to increased T-cell replication. IL-1beta can also act on distant target cells in an endocrine manner to induce systemic immune response. IL-1beta can rapidly induce the expression of cytokines such as IL-6 and IL-8 of various cell types. At the same time, IL-1beta also induces its own expression, forming a positive feedback loop and amplifying the IL-1 response