Description
Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotein consisting of a short amino-terminal region, three tandem Kunitz-type domains and a positively chargedcarboxy-terminal tail. TFPI2 inhibits plasmin-dependent activation of several metalloproteinases. TFPI2 ishighly abundant in the full-term placenta and widely expressed in various adult human tissues, such as theliver, skeletal muscle, heart, kidney, and pancreas. The expression of TFPI2 in tumors is inversely related toan increasing degree of malignancy, which may suggest a role for TFPI2 in the maintenance of tumor stabilityand inhibition of the growth of neoplasms. TFPI2 inhibits the tissue factor/factor VIIa (TF/VIIa) complex anda wide variety of serine proteinases including plasmin, plasma kallikrein, factor XIa, trypsin, andchymotrypsin. TFPI2 is involved in regulating pericellular proteases implicated in a variety of physiologic andpathologic processes including cancer cell invasion, vascular inflammation, and atherosclerosis. TFPI2 hasalso been shown to induce apoptosis and inhibit angiogenesis, which may contribute significantly to tumorgrowth inhibition