Description
Junctional complexes between the plasma membrane and endoplasmic
sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. This protein is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic
sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described