Description
Human PI4KB Recombinant Protein C-6 His Tag has been recombinantly produced in Human Cells.
Phosphatidylinositol 4-Kinase beta (PI4KB) belongs to the PI3/PI4-kinase family and Type III PI4K subfamily. PI4KB contains one PI3K/PI4K domain and one PIK helical domain. It is highly expressed in heart, skeletal muscle, pancreas, testis and ovary, ; it is lowly expressed in liver tissue. PI4KB kinase activity can be inhibited by wortmannin, and increased by interacting with NCS1/FREQ. PI4KB phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1, 4, 5, -trisphosphate (PIP). In addition, PI4KB may regulate Golgi disintegration/reorganization during mitosis.
This recombinant protein can be used for biological assays