Description
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. This protein is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2
TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3
XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene