Description
Human Rhesus macaque SLAMF7/CRACC/CD319 Recombinant Protein His Tag Lyophilized has been recombinantly produced in HEK293 cells.
SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Isoform 1 of SLAMF7 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. Isoform 3 of SLAMF7 does not mediate any NK cell activation.
This protein carries a polyhistidine Tag at the C-terminal. The protein has a calculated MW of 24.4 kDa. The protein migrates as 35-46 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation