Description
Human IL-13 R alpha 2 Recombinant Protein His Tag Lyophilized has been recombinantly produced in HEK293 cells.
Interleukin-13 receptor subunit alpha-2 is also known as IL13Ralpha2, IL13Ra2 cluster of differentiation 213A2, CD213A2, CT19, IL-13R, IL13BP, and is a membrane bound protein that in humans is encoded by the IL13RA2 gene. IL13Ralpha2 is closely related to IL13Ralpha1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL13 and IL4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13. IL13Ralpha2 is a component of the cell surface receptors, however, the majority exists in intracellular pools and in soluble form, and thus plays an opposite role as a potent IL13 anTagonist compared with IL13Ralpha1. It also functions as an inhibitor of IL4-dependent pathway probably through the physical interaction between the short intracellular domain of and cytoplasmic domain of IL13Ralpha2 and the IL4Ralpha chain. In spite of the failed STAT signaling function, IL13Ralpha2 dose induce TGF-beta production and fibrosis. Additionally, IL13Ralpha2 has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme.
This protein carries a polyhistidine Tag at the C-terminal. The protein has a calculated MW of 39.0 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation