Description
Human LIGHT/TNFSF14 Recombinant Protein Fc Tag Lyophilized has been recombinantly produced in HEK293 cells.
Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.
This protein carries a human IgG1 Fc Tag at the N-terminal. The protein has a calculated MW of 44.7 kDa. The protein migrates as 50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation