Description
Human APRIL/TNFSF13 Recombinant Protein His Tag Lyophilized has been recombinantly produced in HEK293 cells.
APRIL(a proliferation-inducing ligand) is also known as Tumor necrosis factor ligand superfamily member 13, TALL-2, TRDL-1, CD256, TNFFSF 13, cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. APRIL is a cytokine of the tumor necrosis factor family associated mainly with hematologic malignancies. The closely related TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes. Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share. BAFF-APRIL heteromers of different stoichiometries have distinct receptor-binding properties and activities. In addition, expression of APRIL was regulated by miR-145 in GC cells.
This protein carries a polyhistidine Tag at the N-terminal. The protein has a calculated MW of 22.8 kDa. The protein migrates as 28 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation