Description
Human IL-4 Receptor Recombinant Protein Lyophilized has been recombinantly produced in HEK293 cells.
IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (gammac). The type I receptor contains in addition to the gamma chain an IL-4Ralpha subunit, whereas the type II receptor contains the IL-13Ralpha. The secreted extracellular domain of IL-4Ralpha, called sIL-4Ralpha, binds IL-4 and anTagonizes its activity. It plays an important role in regulating the differentiation of naive CD4 T cells and class switching to IgG1 and IgE. Recombinant Human sIL-4Ralpha is a 209 amino acid protein that corresponds to the entire extracellular domain of IL-4Ralpha