Description
Human CD123 (Interleukin 3 Receptor alpha) is a 70kD type I transmembrane molecule, and is the low affinity receptor for the cytokine IL-3, which can stimulate proliferation or differentiation. When paired in a heterodimer with CD131 (IL-3 R beta), it binds IL-3 with much higher affinity. CD123 is found on Myeloid precusors, Stem cells, a subset of T cells, some B cells Megakaryocytes, basophils, monocytes and epithelial cells. CD123 is present at high levels on many hematologic malignancies and antibodies(2) and CAR T cells(1). Antibodies against CD123 have been used successfully to combat Acute Myeloid Leukemia (2)