Description
This protein belongs to the family of Na+
K+ and H+
K+ ATPases beta chain proteins, and to the subfamily of Na+
K+ -ATPases. Na+
K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha
beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+
K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified