Description
Introduction: SEMA3C, also known as Semaphorin 3C, is a member of the semaphorin family 3 that are grouped into 8 major classes based on phylogenetic tree analyses and structure. Class 3 have an important function after traumatic central nervous system injuries. SEMA3C regulates neuronal and non-neuronal cells associated with the traumatic injury due to their presence in the scar tissue. SEMA3C is expressed in all somatic motor neurons, in cardiac neural crest cells during development and in lung buds. The SEMA3C functions are mediated through binding to the Plexin-D1 and Neuropilin 1 or Neuropilin 2 coreceptor complex. SEMA3C activates integrins in certain cells, so besides its repulsive activities, it also acts as a chemoattractant.
Description: SEMA3C Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (21-738 a.a) containing a total of 951 amino acids, having a molecular mass of 107.2kDa. SEMA3C is fused to a 233 amino acid hIgG-Tag at C-terminus,and is purified by proprietary chromatographic techniques