Description
Mouse TSLP Recombinant Protein His Tag Lyophilized has been recombinantly produced in HEK293 cells.
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.
This protein carries a polyhistidine Tag at the C-terminal. The protein has a calculated MW of 15.9 kDa. The protein migrates as 23-27 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation