Description
Human TACI/TNFRSF13B Recombinant Protein Fc Tag Lyophilized has been recombinantly produced in HEK293 cells.
Transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B). It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: BAFF and APRIL. The present study demonstrated that, in NSCLC, a proliferation-inducing ligand (APRIL), B-cell maturation antigen (BCMA)and transmembrane activator and CAML interactor (TACI) proteins are abnormally expressed by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction and western blotting. In addition, the expression of APRIL, BCMA and TACI were observed to be involved in extracellular signal-regulated kinase (ERK)1/2 activation in A549 cells.
This protein carries a human IgG1 Fc Tag at the C-terminal. The protein has a calculated MW of 44.6 kDa. The protein migrates as 33-34 kDa, 35 kDa and 50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation