Description
PKC iota, also known as Protein Kinase C iota, is a member of serine/threonine protein kinases family. It play a key regulatory role in a number of cellular functions including cell growth and differentiation, hormone secretion, and gene expression. It is involved in cell polarization processes and the formation of epithelial tight junctions. This protein kinase is calcium-independent and phospholipid-dependent. It is also implicated in the activation of several signaling pathways including Ras, c-Src and NF-kappa-B pathways. Recombinant human PKC iota, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques