Description
E2F-2 (viral E2-associated factor 2) is a 50?55 kDa member of the E2F/DP family of transcription factors. It is principally expressed by placenta, and forms a DNA?activating E2F heterodimeric complex with DP-1 or -2. This complex, when active, promotes cell cycle progression. In quiescent cells, association of E2F-2 with the retinoblastoma-tumor suppressor gene product termed pRB suppresses its activity