Description
It is a cell penetrating peptide consisting of amino acids 1 to 20 of influenza A virus hemagglutinin protein (HA2), which is linked to a 10 amino acid cell permeable HIV Trans-activator of Transcription (TAT) protein transduction domain (PTD). TAT-HA2 can be used as a large molecule drug delivery peptide. TAT PTD binds to the cell surface and penetrates the cell membrane through lipid raft dependent macropinocytosis. The HA2 domain is a pH-sensitive lipid membrane destabilizing sequence that enhances endosomal escape and transduction of the fusion peptide