Description
A peptide inhibitor of the PD-1-PD-L1 protein-protein interaction; binds to PD-L1 in a cell-free assay (Kd = 94.67 nM); reverses PD-L1-induced decreases in IFN-γ levels in anti-CD3-induced isolated human CD4+ T cells at 20 µM; reduces tumor volume in a mouse xenograft model using HL-60 leukemia cells co-cultured with anti-CD3-activated isolated human CD4+ T cells prior to implantation