Description
Product Characteristics: Recombinant Menin (MEAI), Prokaryotic expression, Gly219-Pro395, N-terminal His Tag
antibodies-online can provide customization with regards to expression system, tag location and sequence for our made to order proteins designed and produced in Germany. Please contact our customer support for further information.:
Target Information: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4) (By similarity). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression (By similarity). Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity (By similarity). Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA (By similarity). Positively regulates HOXC8 and HOXC6 gene expression (By similarity). May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair