Description
Product Characteristics: EBV EBNA-1, Recombinant,EBV EBNA-1, Recombinant Epstein-Barr Virus (EBV) Epstein-Barr Virus Nuclear Antigen-1 (EBNA-1), Recombinant Recombinant produced from the ORF of the BKRF1 gene of EBV. Contains a His-tag in its N-terminus. Molecular weight calculated from the amino acid sequence is 63 kDa.
antibodies-online can provide customization with regards to expression system, tag location and sequence for our made to order proteins designed and produced in Germany. Please contact our customer support for further information.:
Target Information: Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival (By similarity)