Knocking down of LOX protein caused a reduction in the number of viable cells., which can be rescued by OriGene LOX protein (TP313323). Figure cited from EMBO Mol Med 2015. PMID: 26077591

An increased number of metastatic cells was found in the lungs of mice injected with OriGene recombinant LOX protein (TP313323) compared to control mice injected with PBS. Figure cited from Cell Rep 2017. PMID: 28445728

Injection of recombinant LOX (rLOX, TP313323) into both immune-compromised nude and immune-competent BALB/c mice led to (A) the formation of focal osteolytic lesions; (B) increased circulating carboxy terminal telopeptide (CTX), a biomarker of bone turnover. Figure cited from Nature Jun 2015. PMID: 26017313

Addition of recombinant LOX (rLOX, TP313323) to pre-osteoclast cultures can generate greater numbers of osteoclasts with a higher resorptive capacity than RANKL-stimulated cultures. arrow = osteoclast, arrowheads = resorption tracks. (n: osteoclast count from 12 independent osteoclast assays per group). Figure cited from Nature Jun 2015. PMID: 26017313