Description
Arp2/3 complex is a seven-subunit protein that plays a major role in the regulation of the actin cytoskeleton and is found in most in eukaryotic cells. Two of its subunits, the Actin-Related Proteins ARP2 and ARP3 closely resemble the structure of monomeric actin and serve as nucleation sites for new actin filaments. The complex binds to the sides of existing ("mother") filaments and initiates growth of a new ("daughter") filament at a distinctive 70 degree angle from the mother. Branched actin networks are created as a result of this nucleation of new filaments. The Arp2/3 complex (molecular weight of 224 kDa) is a key regulator of branched actin filament nucleation and is important for cell locomation, phagocytosis and intracellular motility