Colivelin TFA HY-P1061A from MedChemExpress

Product Specs
ItemColivelin TFA
CompanyMedChemExpress
Price $190.00Supplier Page View Company Product Page
Catalog NumberHY-P1061A
Size500 µg
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.52%
TypeChemical
Molecular Weight2759.12
FormulaC₁₁₉H₂₀₆N₃₂O₃₅.C₂HF₃O₂
Research AreaNeurological Disease

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(1) Celastrol ameliorates atherosclerosis by inhibiting TLR4/STAT3/NLRP3-mediated macrophage pyroptosisChin MedMay 28, 2026Yaning Shi, Ziyi Li, Qizhi Liu, Yun Qiu, Junpeng Long, Qiong Yang, Chanjuan Zhang, Yongzhen Gong, Li QinqPCR kit (RR047A) were purchased from Takara (Kyoto, Japan). Nigericin (HY-127019) and colivelin TFA (HY-P1061A) were obtained from MedChemExpress (New Jersey, USA). Atorvastatin calcium (ATV, 100,590) was purchased

(2) Astrocytic GSTM2-STAT3 interaction ameliorates the diabetes associated cognitive dysfunction via targeting mitochondrial defects and oxidative stressRedox BiologyMay 1, 2026Wenqiang Liu, Yufei Wang, Yunshuang Zhao, Bingxue Song, Linqin Luo, Khan Muhammad Zahir, Miaomiao Song, Yong Wang, Li Zhang, Zhongfu Zuo, et al.Ltd.) and intraperitoneal administration of Colivelin-TFA (a selective STAT3 activator, 1 mg/kg/day, HY-P1061A, MCE, USA) [[18], [19], [20]]. Throughout the experimental timeline, fasting blood glucose concentrations

(3) Skeletal stem/progenitor cell-derived rather than osteoblast-derived IGF2 supports the development and homeostasis of skeletal system via STAT3Int J Biol SciApril 28, 2025Tairan Wang, Kunao Zhu, Yi Tang, Yuxing Xia, Qian Zhang, Rong Cong, Chaoqun Pan, Feiwu Kangadministration, 4-wk-old male OsxCre; Igf2fl/- were randomly divided into two groups. Colivelin (MCE, HY-P1061A) at a concentration of 1mg/kg or equal volume of PBS was intraperitoneally injected respectively each

(4) Dapagliflozin improves diabetic cardiomyopathy by suppressing the STAT3-YY1 signaling axis in cardiac fibroblastsIran J Basic Med SciApril 5, 2025Xing-Yi Shen, Xi-Ya Li, Zuo-Ying Hu, Hao Xiesignaling axis in CFs. Materials and Methods Regents Dapagliflozin (#HY-10450) and colivelin TFA (#HY-P1061A) were purchased from MCE (Monmouth Junction, NJ, USA). D-Glucose (#G7528) and D-Mannitol (#M4125) were

(5) Salidroside exerts anti-tumor effects in ovarian cancer by inhibiting STAT3/c-Myc pathway-mediated glycolysisBiomol BiomedDecember 11, 2024Yu G, Feng X.SAL+Colivelin TFA group, cells were co-intervened with 800 µM of SAL and 50 µg/mL of Colivelin TFA (HY-P1061A, MedChemExpress, Monmouth Junction, NJ, USA) for 24 h. Cell counting kit-8 (CCK-8) assay IOSE80, SKOV3,

(6) Aryl hydrocarbon receptor regulates IL-22 receptor expression on thymic epithelial cell and accelerates thymus regenerationNPJ Regenerative medicineNovember 8, 2023Shen J, Wang Y, Zheng F, Cao S, Lan Q, Xu K, Pan B.10% FBS for 72 h. Reagents FICZ (HY-12451), CH-223191 (HY-12684), stattic (HY-13818) and colivelin (HY-P1061A) were purchased from MedChemExpress (Monmouth Junction, NJ, USA). Recombinant murine IL-22 (rmIL-22)

(7) Exercise maintains bone homeostasis by promoting osteogenesis through STAT3International Journal of Biological SciencesApril 2, 2023Xiangru Huang, Yanfei Zhu, Siyuan Sun, Xin Gao, Yiling Yang, Hongyuan Xu, Anting Jin, Yuanqi Liu, Hanbing Jia, Qinggang Dai, et al.expressing either CRE recombinase or GFP at a multiplicity of infection of 50. For colivelin (MCE, HY-P1061A) treatment, BMSCs were seeded in 96-well plates at a density of 1.0 × 105. The changed medium was treated

(8) Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NF-κB signaling pathwayPhytomedicine : international journal of phytotherapy and phytopharmacologyJanuary 1, 2023Li C, Li Y, Zhang H, Zhuo Y, Zhang L, Yang L, Gao Q, Tu Z, Shao R, Wang Y, et al.ABclonal Technology (Wuhan, China). The complement C5a(HY-P7695) and STAT3 activator Colivelin TFA(CAF, HY-P1061A) were obtained from MCE (Shanghai, China). IgG IC-induced acute lung injury Pathogen-free male C57BL/6

(9) Sphingomyelin synthase 2 is a positive regulator of the CSF1R-STAT3 pathway in pancreatic cancer-associated macrophageFrontiers in pharmacologyJanuary 1, 2022He S, Gu X, Yang J, Xu F, Hu J, Wang W, Huang Y, Lou B, Ding T, Zhou L, et al.School of Pharmacy, Fudan University (CN202210213012.7). The activator of STAT3 is colivelin TFA (MCE, HY-P1061A). Bioinformatics analysis The GEPIA website (http://gepia.cancer-pku.cn) was used to analyze the expression

(10) Ac2-26 attenuates hepatic ischemia-reperfusion injury in mice via regulating IL-22/IL-22R1/STAT3 signalingPeerJJanuary 1, 2022Li W, Jiang H, Bai C, Yu S, Pan Y, Wang C, Li H, Li M, Sheng Y, Chu F, et al.Qiang Yao Biotechnology Company (Shanghai, China). Hoechst 33342 (HY-15559) and colivelin TFA (CLN, HY-P1061A) were obtained from MedChemExpress (Monmouth Junction, NJ, USA). Hydrogen peroxide (H2O2, 18304), trypan

(11) STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesisNature communicationsNovember 25, 2021Zhou S, Dai Q, Huang X, Jin A, Yang Y, Gong X, Xu H, Gao X, Jiang L.Hence, we raised the question whether pharmacological activation of STAT3 activity by colivelin (MCE, HY-P1061A) could be applied for therapy regarding skeletal deformities in the STAT3 heterozygous mice47. Firstly,

(12) RIPK4 Suppresses the Invasion and Metastasis of Hepatocellular Carcinoma by Inhibiting the Phosphorylation of STAT3Frontiers in Molecular BiosciencesJune 18, 2021Haoran Li, Dingan Luo, Lakshmi Huttad, Mao Zhang, Youpeng Wang, Juan Feng, Yunfeng Ding, Bing Han95% air and 5% CO2 at 37°C. Colivelin, an activator of the STAT3 pathway, was purchased from MCE (No. HY-P1061A; Shanghai, China). Lentivirus Transfection We reconstructed the overexpression vector with the purchased

(13) MFG-E8 alleviates oxygen-glucose deprivation-induced neuronal cell apoptosis by STAT3 regulating the selective polarization of microgliaThe International journal of neuroscienceJanuary 1, 2021Fang YY, Zhang JH.

(14) Upregulation of HSP72 attenuates tendon adhesion by regulating fibroblast proliferation and collagen production via blockade of the STAT3 signaling pathwayCellular signallingJuly 1, 2020Pan Z, Wu Q, Xie Z, Wu Q, Tan X, Wang X.

(15) Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling PathwayNeuroscienceSeptember 15, 2019Zhao H, Feng Y, Wei C, Li Y, Ma H, Wang X, Cui Z, Jin WN, Shi FD.

(16) The Synthetic β-Nitrostyrene Derivative CYT-Rx20 Inhibits Esophageal Tumor Growth and Metastasis via PI3K/AKT and STAT3 PathwaysPloS oneJanuary 1, 2016Chiu WC, Lee YC, Su YH, Wang YY, Tsai CH, Hou YA, Wang CH, Huang YF, Huang CJ, Chou SH, et al.

(17) Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivoThe Journal of neuroscience : the official journal of the Society for NeuroscienceNovember 2, 2005Chiba T, Yamada M, Hashimoto Y, Sato M, Sasabe J, Kita Y, Terashita K, Aiso S, Nishimoto I, Matsuoka M.

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Colivelin TFA from MedChemExpress

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Colivelin TFA from MedChemExpress

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