IL-4 Protein, Human HY-P70445 from MedChemExpress

Product Specs
ItemIL-4 Protein, Human
CompanyMedChemExpress
Price $280.00Supplier Page View Company Product Page
Catalog NumberHY-P70445
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
TypeProtein
Size50 µg
Molecular Weight13-14 kDa
Source/Expression SystemE. coli
ActivityThe cell proliferation assay using TF 1 human erythroleukemic cells has an ED50 value of 7-44 pg/mL
SpeciesHuman
NCBI Full Gene Nameinterleukin 4
NCBI Gene AliasesBSF1, IL-4, BCGF-1, BSF-1, BCGF1

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(1) NIR-Activated ICG-Loaded M2 Macrophage Exosomes Ameliorate Periodontitis via Targeting Infection Inflammation and Oxidative StressResearch (Wash D C)April 27, 2026Xincong Mao, Xincong Li, Tianyu Zhang, Xiaofan Zhang, Xiaofan Zhuang, Zhilei Zhuang, Shoushan Buthe differentiated macrophages for 24 h with a cytokine cocktail containing 20 ng/ml of both IL-4 (HY-P70445, MCE, USA) and IL-13 (HY-P70568, MCE, USA). To generate the experimental group, these M2 macrophages

(2) C-terminal Fragment Generated by HOIL-1 Cleavage Suppresses Inflammatory Responses of Myeloid Cells to Alleviate ColitisTheranosticsFebruary 11, 2026Xiaomeng Li, Hefan Zhang, Qian Wang, Qianqian Li, Xingru Wang, Yu Tian, Rui Zhang, Qiuyun Chen, Christopher M. Overall, Stuart E. Turvey, et al.stimulated with human IFN-γ (20 ng/mL) and LPS (100 ng/mL) for 12 h or with human IL-4 (20 ng/mL) (MCE, HY-P70445, Monmouth Junction, NJ, USA) for 24 h to induce M1- or M2-type polarization, respectively. For NLRP3

(3) Hypoxia-Induced Osteopontin-Positive Glioma-Associated Macrophages Facilitate Glioma Mesenchymal Transition via NF-κB Pathway ActivationCancer CommunicationsJanuary 23, 2026Jingchen Yang, Xuejing Li, Xiaoxue Zhu, Ziwei Li, Xiaoyong Chen, Ruoyu Huang, Mingchen Yu, Bo Han, Tao Jiang, Chuanbao Zhang, et al.additional 48 h. Unstimulated macrophages were polarized with 20 ng/ml interleukin-4 (IL-4; catalog no. HY-P70445, MedChemExpress) and 20 ng/ml IL-13 (catalog no. HY-P70568, MedChemExpress) for another 48 h [47]. Overall,

(4) HMGB1 impairs nasal mucosa epithelial barrier function in allergic rhinitis by promoting BECN1-mediating autophagyBiochemistry and Biophysics ReportsDecember 1, 2025Zhaoen Ma, Langrui Tu, Xiaobin Yang, Min Mao, Guangui Chen, Fenghong Chen, Libing Liao, Yali Xutransfection solution was removed and replaced with complete culture medium containing 10 ng/ml of IL-4 (HY–P70445, MCE, USA) with or without 2 μg/ml of recombinant HMGB1 protein (HY–P72797, MCE) for 48 h. 2.4 Reverse

(5) Omentin-1 reduced synovial M1 macrophages through SIRT6 signaling pathway and alleviated knee osteoarthritis response in miceArthritis Research & TherapyNovember 18, 2025Hao Wu, Weixue Sun, Qian Zhang, Gong Cheng, Zhilin Cao(HY-P7025A, MCE) and 10pg/mL LPS (HY-D1056, MCE) for 24 h, and into M2 macrophage with 20ng/mL IL-4 (HY-P70445, MCE) and 20ng/mL IL-13 (HY-P70568, MCE) for 24 h [22]. In Omentin-1 group, after stimulation, RAW264.7

(6) DPEP2 suppresses metastasis via NF-κB-mediated epithelial-mesenchymal transition and M2 polarization in p53-loss non-small cell lung cancerCancer Cell InternationalNovember 17, 2025Yongting Liu, Yulong Zhao, Ziyu Dai, Jingyi Wang, Jingyi Sun, Shasha Yang, Ruixin Ma, Qiong Chenactivation of M0 macrophages. To induce M2 polarization, M0 macrophages were stimulated with 20 ng/mL IL4 (HY-P70445, MCE) and IL13 (HY-P70568, MCE) for 24 h, as previously described [16, 17]. Lentivirus infection assay Lentivirus infection

(7) Elevated lactate production exacerbates PM2.5-induced pulmonary fibrosis by stabilizing TGF-β1Journal of Advanced ResearchAugust 5, 2025Zhihao Liu, Wei Liu, Huaiqing Wei, Yiping Ping, Zhenjie Yu, Zheng Dong, Jiayu Ren, Shuping Zhang, Sijin Liu(cat#HY-17565A), LDHA-IN-3 (cat# HY-139319), 2-DG (cat#HY-13966), Mouse IL-4 (cat#HY-P7080), and Human IL-4 (cat# HY-P70445) (MCE, USA); DNase I (cat#18047019), Collagenase IV (cat#17104019), Compensation microspheres (cat#

(8) Macrophages form dendrite-like pseudopods to enhance bacterial ingestionThe EMBO JournalJuly 28, 2025Changyuan Fan, Xinyi Huang, Jie Mei, Xuemeng Shi, Hao Zhang, Cong Liang, Shuzhi Cui, Yifan Xing, Biao Cao, Wei Liu, et al.anti-CD14 antibodies. These monocytes were treated with 100 ng/mL GM-CSF (#HZ-1002, Proteintech) and IL-4 (#HY-P70445, MedChemExpress) for 5 days, with media and cytokines replaced on day 5 to generate moDCs. These moDCs

(9) Oncogenic CMTM6 drives M2a macrophages formation and fuels cervical cancer progressionFrontiers in ImmunologyJuly 21, 2025Bo Yin, Chun Chen, Baoyou Huang, Jianyi Ding, Haoran Hu, Huijuan Zhou, Yashi Zhu, Tiefeng Huang, Xiang He, Yuan Lu, et al.China) in RPMI 1640 medium without FBS for 48 h. Macrophages treated with 20 ng/ml interleukin 4 (IL-4) (HY-P70445, MedChemExpress, China) for 24 h were polarized into M2 phenotype (6). To investigate the effects of

(10) Upregulated Hexokinase-2 in Airway Epithelium Regulates Apoptosis and Drives Inflammation in Asthma via Peptidylprolyl Isomerase FCellsJuly 1, 2025Tian Z, Zheng H, Fan Y, Li B, Huang Z, Wang M, Zhang J, Zhao J, Wang S, Xie J.Cambridge, MA, USA, ab182858,RRID: AB_182858), recombinant IL-4 (MedChemExpress, Monmouth Junction, NJ, USA, HY-P70445), recombinant IL-13 (MedChemExpress, New Jersey, USA, HY-P70568), recombinant IL-6 (MedChemExpress,

(11) Nuclear PHGDH regulates macrophage polarization through transcriptional repression of GLUD1 and GLS2 in breast cancerCancer Biology & MedicineMay 28, 2025Pei Wang, Xin Du, Zhiren Han, Jiaxin Zhong, Jiayu Yuan, Lin Jiang, Beinan Han, Wenkui Fu, Hongde Li, Hai Hu, et al.differentiation. For M2 polarization, M0 macrophages were stimulated with 20 ng/mL IL-4 (MCE, Cat. HY-P70445) and 20 ng/mL IL-13 (MCE, Cat. HY-P70568) for 48 h. For induction of TAMs, MDA-MB-231 cell conditioned

(12) Defining gastric cancer ecology: the crucial roles of TREM2(+) macrophages and fibroblasts in tumor microenvironmentsCommunications biologyMarch 28, 2025Cao Q, Sun D, Tu C, Wang J, Fu R, Gong R, Xiao Y, Liu Q, Li X.Subsequently, the macrophages were treated with LPS (100 ng/mL, HY-P7025A, MedChemExpress) and IL-4 (20 ng/mL, HY-P70445, MedChemExpress) for 24 h each to polarize into M1 and M2 macrophages, respectively (Fig. S9A), for

(13) Circulating mitochondrial DNA promotes M2 polarization of tumor associated macrophages and HCC resistance to sorafenibCell Death DisMarch 4, 2025Qi Yang, Mengmeng Cui, Jiaxin Wang, Yuan Zhao, Weitao Yin, Ziqian Liao, Yixuan Liang, Zhixiong Jiang, Yujia Li, Jinrong Guo, et al.incubated with 20 ng/mL IL-13 (MedChemExpress, cat. HY-P70568) and 20 ng/mL IL-4 (MedChemExpress, cat. HY-P70445) for 24 h to polarize into the M2 phenotype. The supernatant was collected and filtered using 0.22 μm

(14) Silencing SPP1 in M2 macrophages inhibits the progression of castration-resistant prostate cancer via the MMP9/TGFβ1 axisTranslational andrology and urologyJuly 31, 2024Chen S, Deng B, Zhao F, You H, Liu Y, Xie L, Song G, Zhou Z, Huang G, Shen W.MCE, Monmouth Junction, NJ, USA] to generate M0 macrophages, followed by induction with IL-4 (MCE, Cat#HY-P70445) to generate M2 macrophages. Subsequently, Lipo3000 transfection reagent (Thermo Fisher Scientific,

(15) SHP-2-induced M2 polarization of tumor associated macrophages via IL-4 regulate colorectal cancer progressionFrontiers in OncologyJanuary 26, 2023Zhihan Li, Jinchuan Xi, Baokun Li, Youqiang Liu, Guiying Wang, Bin Yu, Hongqing Ma, Zhilin Li, Zhenya Zhangmacrophages. Furthermore, 10 μm of SHP-2 inhibitors PHPS1 (brand: MCE, HY-112368) and/or 15 ng/mL IL-4 (MCE, HY-P70445) and/or 30 μM of PI3K inhibitors LY294002 (MCE, HY-10108) was added into the medium and incubated for

(16) TcpC Inhibits M1 but Promotes M2 Macrophage Polarization via Regulation of the MAPK/NF-κB and Akt/STAT6 Pathways in Urinary Tract InfectionCellsAugust 28, 2022Fang J, Ou Q, Wu B, Li S, Wu M, Qiu J, Cen N, Hu K, Che Y, Ma Y, et al.Louis, MO, USA), IFN-γ (HY-P7025, MedChemExpress, Monmouth Junction, NJ, USA) and Interleukin-4 (IL-4) (HY-P70445, MedChemExpress, Monmouth Junction, NJ, USA); LPS-free recombinant TcpC (rTcpC) was prepared in our

(17) Matrix Remodeling-Associated Protein 8 as a Novel Indicator Contributing to Glioma Immune Response by Regulating FerroptosisFrontiers in ImmunologyFebruary 24, 2022Zhijie Xu, Xi Chen, Liying Song, Fang Yuan, Yuanliang Yanh. To polarize M2 macrophages, cells were then treated with M2-polarizing reagents IL-4 (20 ng/ml; HY-P70445, MedChemExpress, USA) plus IL-13 (20 ng/ml; 200-13-10UG, Peprotech, USA) and incubated at 37°C for 72

(18) Potent in vitro and in vivo antitumor activity of interleukin-4-conjugated Pseudomonas exotoxin against human biliary tract carcinomaInternational journal of cancerDecember 15, 2008Ishige K, Shoda J, Kawamoto T, Matsuda S, Ueda T, Hyodo I, Ohkohchi N, Puri RK, Kawakami K.

(19) Interleukin-4 receptor cytotoxin as therapy for human malignant pleural mesothelioma xenograftsThe Annals of thoracic surgeryAugust 1, 2004Beseth BD, Cameron RB, Leland P, You L, Varricchio F, Kreitman RJ, Maki RA, Jablons DM, Husain SR, Puri RK.

(20) IL-4 enhances proliferation and mediator release in mature human mast cellsProceedings of the National Academy of Sciences of the United States of AmericaJuly 6, 1999Bischoff SC, Sellge G, Lorentz A, Sebald W, Raab R, Manns MP.

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IL-4 Protein, Human from MedChemExpress

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IL-4 Protein, Human from MedChemExpress

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