Description
KYL peptide, an antagonistic peptide, selectively targets EphA4 receptor (IC50:4.22 µM, Kd:1.3 µM). KYL peptide binds to the ligand-binding domain of EphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses