TGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293, Tag Free) HY-P7117 from MedChemExpress

Product Specs
ItemTGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293, Tag Free)
CompanyMedChemExpress
Price $500.00Supplier Page View Company Product Page
Catalog NumberHY-P7117
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
TypeProtein
Size50 µg
Molecular WeightApproximately 13 kDa
Source/Expression SystemHEK293
Activity1) Measured by its ability to inhibit IL-4-dependent proliferation of TF-1 human erythroleukemic cells and the ED₅₀ is 5-25 pg/mL. 2) Measured by its ability to inhibit cell proliferation of Mv-1-lu mink lung epithelial cells. The ED₅₀ for this effect is 0.2-0.8 ng/mL
SpeciesRat, Mouse
NCBI Full Gene Nametransforming growth factor, beta 1
NCBI Gene AliasesTGF-beta1, Tgfb, TGFbeta, TGF-beta, TGFbeta1, Tgfb-1

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(1) Apolipoprotein E knockout attenuates vascular graft fibrosis by reducing profibrotic macrophage formation through low-density lipoprotein receptor related protein 1Bioactive MaterialsJune 1, 2026Jiayin Fu, Meng Zhao, Jing Zhao, Shaofei Wu, Jiahui Wu, Xulin Hong, He Huang, Guosheng Fu, Shengjie Xuto 8 were used in this study. Exogenous APOE (0.25 μg/mL, MCE, HY-P701096), TGF-β1 (10 ng/mL, MCE, HY-P7117), IGF-1 (10 ng/mL, MCE), conditioned medium by macrophages, or IGF-1 blocking antibody (1 μg/mL, Invitrogen,

(2) Helicase A determines the transcription program of TH17 lineage differentiation and autoimmunitySci AdvMay 15, 2026Yanhong Su, Anjun Jiao, Xiaoran Zhang, Yanan Xu, Huanxin Ping, Kun Zhu, Qiaohao Wang, Ning Yuan, Yang Gao, Bomiao Ju, et al.anti-mouse IFN-γ antibody (10 μg/ml; clone XMG1.2, BioLegend); TH17: mTGF-β1 (0.5 ng/ml; catalog no. HY-P7117, MCE) and mIL-6 (50 ng/ml; catalog no. 575704, BioLegend); iTreg: mTGF-β1 (1 ng/ml) and mIL-2 (50 U/ml).

(3) Cardiomyocyte-derived BDNF restricts cardiac fibrosis by decreasing the activity of the TGF-β/Smad2/3 pathway and increasing Smad7 expressionFrontiers in Cell and Developmental BiologyApril 28, 2026Yu Zhu, Yuanfei Ran, Tingting Fu, Xin Zheng, Yanjun Chen, Chunbao Liang, Yanmei Li, Ruijin Huang, Hui Zhao, Xiudi Pan, et al.preparation of CMFs, the CFs were isolated and cultured as described above. Then, 10 ng/mL TGF-β1 (HY-P7117, MCE) was added to cultured CFs to induce CMF differentiation for 24 h. Anti-α-SMA (ab5694; Abcam) immunofluorescence

(4) Magnesium-tannic acid nanomedicines reprogram pro-fibrotic macrophages for hepatic fibrosis treatment via restoring endoplasmic reticulum homeostasisJournal of NanobiotechnologyApril 18, 2026Xin Zhao, Chunjie Wang, Zun Fan, Qingyu Kong, Liangzhu Feng, Lei Qinpurchased from AbMole Bioscience (Houston, TX, USA). CCl4 (HY-Y0298), olive oil (HY-108749), TGF-β (HY-P7117), TG (HY-13433), and DCFH-DA fluorescent probe (HY-D0940) were purchased from MedChemExpress (Monmouth

(5) ML216 Alleviates Age-Related Cardiac Fibrosis by Suppressing TGF-β1 Signaling PathwayInt J Mol SciApril 10, 2026Wenbin Liu, Feng Cui, Xiaodan Huang, Na Liang, Jun LiReagents and Antibodies Isoproterenol hydrochloride (HY-B0468), ML216 (HY-12342) and TGF-β1 protein (HY-P7117) were purchased from MCE (Monmouth Junction, NJ, USA). Wheat Germ Agglutinin Conjugates (90-2504) was

(6) SMAD7 Downregulation Promotes Ferroptosis in Pulmonary Arterial Hypertension Via the TGF-β1-SMAD2/3 PathwayShockMarch 26, 2026Wenhui Huang, Xueying Wang, Wenteng Wu, Yue Wang, Xiaolan Chen, Kun Yu, Hongjin Liu, Hui Zhangfresh medium with 5% CO2 and 21% O2 (28). Following the instructions, rat recombinant TGF-β1 (TGF-β1, HY-P7117, MedChemExpress) was prepared over 48 hours. In the experiments, TGF-β1 was used at a concentration

(7) Single cell atlas decodes the molecular dynamics of scar repair after human rotator cuff tearBone ResFebruary 5, 2026Yiming Qin, Guang Yang, Tao Zhang, Yuying Yang, Liyang Wan, Tao Zhang, Linfeng Wang, Zhiyu Hu, Zhu Dai, Hongkang Zhou, et al.assigned to four groups: Control; TGF-β1 group, treated with recombinant TGF-β1 protein (MedChemExpress, HY-P7117, 10 ng/mL); OPN group, treated with recombinant OPN protein (MedChemExpress, HY-P79222, 1 μg/mL); TGF-β1

(8) Lactate attenuates hepatic ischemia-reperfusion injury by reducing intrahepatic Inflammation and suppressing hepatocyte-neutrophil interaction via the IL-33/ST2 pathwayCell Communication and SignalingJanuary 15, 2026Peiyang Fang, Zihan Zhang, Jingjing Zhu, Haozhe Xu, Xiaotong Han, Nan Xu, Xiyu Wang, Longyang Zhou, Xiaonan Du, Hua Jin, et al.p-AKT inhibitor MK2206 (HY-108232, MCE), 10 µM p-AKT agonist SC79 (HY-18749, MCE), 5 ng/mL TGF-β1 (HY-P7117, MCE), PDGF-BB (HY-P7087, MCE), 25 ng/mL IL-1β (HY-P7073, MCE), 20 ng/mL TNF-α (HY-P7090, MCE), 10 ng/mL

(9) Aldose Reductase Mediated Mitophagy Promotes Epithelial-Mesenchymal Transition of HepatocytesHepat MedOctober 1, 2025Jingjing Yan, Wenke Zhao, Haoyu Wang, Lutan Zhou, Xianwei Li, Guannan Wangdiseases. Materials and Methods Materials Epalrestat (EPS; No. HY-66009) and TGF-β1 protein (No. HY-P7117) were acquired from Med Chem Express (MCE). CCl4 was obtained from Sigma (No. 488488). The test kits

(10) Aldose Reductase Mediated Mitophagy Promotes Epithelial-Mesenchymal Transition of HepatocytesHepat MedOctober 1, 2025Jingjing Yan, Wenke Zhao, Haoyu Wang, Lutan Zhou, Xianwei Li, Guannan Wangdiseases. Materials and Methods Materials Epalrestat (EPS; No. HY-66009) and TGF-β1 protein (No. HY-P7117) were acquired from Med Chem Express (MCE). CCl4 was obtained from Sigma (No. 488488). The test kits

(11) Mitochondria-target ubiquinone attenuates bleomycin-induced pulmonary fibrosisFrontiers in PharmacologySeptember 4, 2025Ying Jiang, Zhenghui Huang, Ting Zhou, Mi Wu, Juan Zhao, Zheyi Xiong, Rui Wang, Limin Chen, Xiufang Weng, Lan Linpenicillin/streptomycin at 37 °C and 5% CO2. Cells (2 × 105) were treated with 10 ng/mL recombinant mouse TGF-β1 (HY-P7117, MCE, China), human TGF-β1 (#100–21, Peprotech, USA) or 1 μg/mL bleomycin (CAS No. 9041–93-4, MCE, China),

(12) Nedd4L signaling contributes to carbon tetrachloride-induced liver fibrosis in female mice and is associated with enteric dysbacteriosisGastroenterol Rep (Oxf)March 10, 2025Cheng Chen, Yanghui Bi, Bangtao Chen, Song HeChina). To mimic fibrosis by inducing HSC activation, various doses (1, 2, and 4 ng/mL) of TGFβ1 (#HY-P7117; MedChemExpress) were administered for 72 h. In addition, EMD638683 at 1 μM was given 6 h prior to TGFβ1

(13) Piezo1 facilitates the initiation and progression of renal fibrosis by mediating cell apoptosis and mitochondrial dysfunctionRenal failureDecember 1, 2024Zhang Y, Lv L, Zhou Z, Zhang H, Li Q, Yang S, Wen Y, Wang Q, Feng J, Lu W, et al.plates for 24 h, after which the cells were treated with Yoda1(4 µm), TGFβ1(10 ng/ml) (MedChemExpress, HY-P7117, China) and/or GsMTx4 (4 µm) for 24 h. The intracellular calcium concentration was measured with a Fluo-4

(14) SLC14A1 and TGF-β signaling: a feedback loop driving EMT and colorectal cancer metachronous liver metastasisJournal of Experimental & Clinical Cancer ResearchJuly 27, 2024Yixun Zhang, Yumeng Yang, Xuan Qi, Peng Cui, Yi Kang, Haiyi Liu, Zhigang Wei, Haibo Wangthe study utilized the following reagents: MG132 (HY-13259, MedChemExpress, Shanghai, China); TGF-β1 (HY-P7117, MedChemExpress, Shanghai, China); SB431542 (HY-10431, MedChemExpress, Shanghai, China), anti-TGF-β1

(15) Long intergenic non-coding RNA DIO3OS promotes osteosarcoma metastasis via activation of the TGF-β signaling pathway: a potential diagnostic and immunotherapeutic target for osteosarcomaCancer Cell InternationalSeptember 26, 2023Jinghong Yuan, Jingyu Jia, Tianlong Wu, Zhi Du, Qi Chen, Jian Zhang, Zhiwen Wu, Zhao Yuan, Xiaokun Zhao, Jiahao Liu, et al.after 36 h of SaoS-2 and U2OS transfection, cells were treated with TGF-β1 (MedChemExpress, Cat. No HY-P7117) at a concentration of 10 ng/ml in complete medium 12 h. qRT-PCR Total RNA was isolated from cells

(16) LncRNA GAS5 suppresses TGF-β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoterMolecular MedicineMarch 14, 2023Yichun Wang, Diyu Chen, Han Xie, Shuhua Zhou, Mingwang Jia, Xiaobo He, Feifei Guo, Yihuan Lai, Xiao Xiao TangCell transfection For the induction of fibrogenesis, mouse pulmonary microvascular pericytes were treated with TGF-β1 (HY-P7117, MCE, NJ, USA) for 30 min at 37 °C. The shRNA targeting GAS5 (shGAS5), shPDGFRα, shPDGFRβ, shKDM5B,

(17) Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagyJournal of translational medicineJanuary 13, 2023Wang W, Zhang Y, Huang W, Yuan Y, Hong Q, Xie Z, Li L, Chen Y, Li X, Meng Y.analysis Primary mouse LFs were pretreated with 100 nM ALA for 1 h and then exposed to 4 ng/mL TGF-β1 (HY-P7117, MedChemExpress, USA) for 24 h. Then, the supernatant was collected to measure extracellular lactate

(18) CCL5 promotes LFA-1 expression in Th17 cells and induces LCK and ZAP70 activation in a mouse model of Parkinson's diseaseFrontiers in aging neuroscienceJanuary 1, 2023Zhao J, An K, Mao Z, Qu Y, Wang D, Li J, Min Z, Xue Z.BD Biosciences, 553294) antibodies for 12–16 h. In general, we used the cytokines TGF-β (10 ng/mL, MCE, HY-P7117), IL-23 (10 ng/mL, R&D Systems, United States, 1887-ML) and IL-6 (10 ng/mL, MCE, HY-P7063) to induce

(19) Co-delivery of siPTPN13 and siNOX4 via (myo)fibroblast-targeting polymeric micelles for idiopathic pulmonary fibrosis therapyTheranosticsJanuary 1, 2021Hou J, Ji Q, Ji J, Ju S, Xu C, Yong X, Xu X, Muddassir M, Chen X, Xie J, et al.purchased from Nippon Kayaku (Tokyo, Japan). Recombinant mouse TGF-β1 was obtained from MedChemExpress (no. HY-P7117, Monmouth Junction, NJ). Recombinant mouse Fas Ligand/TNFSF6 protein was received from R&D Systems (no.

(20) Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-β1Translational psychiatryJanuary 27, 2020Zhang K, Yang C, Chang L, Sakamoto A, Suzuki T, Fujita Y, Qu Y, Wang S, Pu Y, Tan Y, et al.

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TGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293, Tag Free) from MedChemExpress

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TGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293, Tag Free) from MedChemExpress

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