Alisporivir HY-12559 from MedChemExpress

Product Specs
ItemAlisporivir
CompanyMedChemExpress
Price $700.00Supplier Page View Company Product Page
Catalog NumberHY-12559
Size1 mg
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity98.92%
TypeChemical
Molecular Weight1216.64
FormulaC₆₃H₁₁₃N₁₁O₁₂
Research AreaInfection

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(1) A preclinical candidate of cyclophilin D inhibition improves alcohol-associated liver injuryCell Rep MedMarch 17, 2026Zhaoyi Che, Zhihui Luo, Dong Xiao, Fashu Ma, Haoxiong Zhou, Yali Song, Shanshan Guo, Yuan Yuan, Hao Wang, Ching-Pong Mak, et al.and recombinant proteins" ,, RN-0001,Farsight Medical Technology,N/A Debio-025,MedChemExpress,Cat#HY-12559 CRV431,MedChemExpress,Cat#HY-135644 ,, Critical commercial assays,Critical commercial assays,Critical

(2) Cyclophilin A stabilizes the capsid protein p72 to facilitate African swine fever virus replicationNature CommunicationsMarch 7, 2026Hui Kong, Liqin Yang, Zhenjiang Zhang, Ying Zhang, Linlin Liu, Wan Wang, Linfei Song, Yuanmao Zhu, Encheng Sun, Fang Li, et al.Cycloheximide (CHX; #66-81-9) was ordered from Merck. Cyclosporine A (CsA; #HY-B0579), Alisporivir (#HY-12559), and NIM811 (#HY-P0025) were obtained from MCE. Alignment of amino acid sequences Gene sequences

(3) DR5 Disulfide Bonding Functions as a Sensor and Effector of Protein Folding StressMolecular Cancer ResearchJuly 2, 2025Mary E. Law, Zaafir M. Dulloo, Samantha R. Eggleston, Gregory P. Takacs, Grace M. Alexandrow, Young il Lee, Mengxiong Wang, Brian Hardy, Hanyu Su, Bianca Forsyth, et al.(HY-12661A), CCF642 (HY-100430), Securinine (HY-N2079), LOC14 (HY-100432), 16F16 (HY-124866), Alisporivir (HY-12559), and VPS34 inhibitor Vps34-IN-1: MedChemExpress (Monmouth Junction, NY, USA); FK506: InvivoGen (San

(4) DR5 disulfide bonding functions as a sensor and effector of protein folding stressMol Cancer ResJuly 2, 2025Mary E. Law, Zaafir M. Dulloo, Samantha R. Eggleston, Gregory P. Takacs, Grace M. Alexandrow, Young il Lee, Mengxiong Wang, Brian Hardy, Hanyu Su, Bianca Forsyth, et al.(HY-12661A), CCF642 (HY-100430), Securinine (HY-N2079), LOC14 (HY-100432), 16F16 (HY-124866), Alisporivir (HY-12559), and VPS34 inhibitor Vps34-IN-1: MedChemExpress (Monmouth Junction, NY, USA); FK506: InvivoGen (San

(5) Alisporivir Normalizes Mitochondrial Function of Primary Mouse Lung Endothelial Cells Under Conditions of HyperglycemiaBiochemistry (Moscow)September 26, 2022Vlada S. Starinets, Dmitriy A. Serov, Nikita V. Penkov, Natalia V. Belosludtseva, Mikhail V. Dubinin, Konstantin N. Belosludtsevwere incubated with 5 µM alisporivir. Alisporivir (Medchemexpress, Monmouth Junction, USA, cat. no. HY-12559) was added to the culture medium as a solution in DMSO (1 : 2000 dilution), cells without alisporivir

(6) Alisporivir Normalizes Mitochondrial Function of Primary Mouse Lung Endothelial Cells Under Conditions of HyperglycemiaBiochemistry (Mosc)July 15, 2022Vlada S. Starinets, Dmitriy A. Serov, Nikita V. Penkov, Natalia V. Belosludtseva, Mikhail V. Dubinin, Konstantin N. Belosludtsevwere incubated with 5 µM alisporivir. Alisporivir (Medchemexpress, Monmouth Junction, USA, cat. no. HY-12559) was added to the culture medium as a solution in DMSO (1 : 2000 dilution), cells without alisporivir

(7) A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targetsPLOS BiologyDecember 28, 2021Annika Kratzel et al.,Thermo Fisher Scientific,4444434 Inhibitors and compounds,Inhibitors and compounds,Inhibitors and compounds Alisporivir,MedChemExpress,HY-12559 Bafilomycin A1,Sigma-Aldrich,B1793 Cyclosporine A,Sigma-Aldrich,30024 Rapamyicin,Sigma-Aldrich,S-015 Kits,Kits,Kits Bright-Glo Luciferase Assay System

(8) Effect of the Non-Immunosuppressive MPT Pore Inhibitor Alisporivir on the Functioning of Heart Mitochondria in Dystrophin-Deficient mdx MiceBiomedicinesSeptember 16, 2021Mikhail V. Dubinin, Vlada S. Starinets, Eugeny Yu. Talanov, Irina B. Mikheeva, Natalia V. Belosludtseva, Dmitriy A. Serov, Kirill S. Tenkov, Evgeniya V. Belosludtseva, Konstantin N. Belosludtsevbeginning at 8 weeks of age. Alisporivir (1 mg/mL, Medchemexpress, Monmouth Junction, NJ, USA, cat. no. HY-12559) was dissolved in a mixture of DMSO, ethanol, and sterile saline (12.5:25:62.5 v/v%) and administered

(9) Alisporivir Improves Mitochondrial Function in Skeletal Muscle of mdx Mice but Suppresses Mitochondrial Dynamics and BiogenesisInternational Journal of Molecular SciencesSeptember 10, 2021Mikhail V. Dubinin, Vlada S. Starinets, Eugeny Yu. Talanov, Irina B. Mikheeva, Natalia V. Belosludtseva, Konstantin N. Belosludtsevbeginning at 8 weeks of age. Alisporivir (1 mg/mL, Medchemexpress, Monmouth Junction, NJ, USA, cat. no. HY-12559) was dissolved in a mixture of DMSO, ethanol, and sterile saline (12.5:25:62.5 v/v%) and administered

(10) Alisporivir Treatment Alleviates Mitochondrial Dysfunction in the Skeletal Muscles of C57BL/6NCrl Mice with High-Fat Diet/Streptozotocin-Induced Diabetes MellitusInternational Journal of Molecular SciencesSeptember 2, 2021Konstantin N. Belosludtsev, Vlada S. Starinets, Eugeny Yu. Talanov, Irina B. Mikheeva, Mikhail V. Dubinin, Natalia V. Belosludtsevaday, mice from groups 2 and 4 were treated with Ali (2.5 mg/kg/day, i.p.) for 20 days. Alisporivir (HY-12559, MedChemExpress, Monmouth Junction, NJ, USA) was dissolved in mixture of DMSO, ethanol, and sterile

(11) Effect of the MPT Pore Inhibitor Alisporivir on the Development of Mitochondrial Dysfunction in the Heart Tissue of Diabetic MiceBiology (Basel)August 28, 2021Natalia V. Belosludtseva, Vlada S. Starinets, Irina B. Mikheeva, Dmitriy A. Serov, Maxim E. Astashev, Maxim N. Belosludtsev, Mikhail V. Dubinin, Konstantin N. Belosludtsevmultiple comparison post hoc test. 2.8. Materials Alisporivir was purchased from MedChemExpress (HY-12559, MedChemExpress, Monmouth Junction, NJ, USA). Standardized animal feeds (Adjusted Calories Diet 60/Fat

(12) Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse modelVirus researchJanuary 15, 2017de Wilde AH, Falzarano D, Zevenhoven-Dobbe JC, Beugeling C, Fett C, Martellaro C, Posthuma CC, Feldmann H, Perlman S, Snijder EJ.

(13) The cyclophilin-inhibitor alisporivir stimulates antigen presentation thereby promoting antigen-specific CD8(+) T cell activationJournal of hepatologyJune 1, 2016Esser-Nobis K, Schmidt J, Nitschke K, Neumann-Haefelin C, Thimme R, Lohmann V.

(14) The cyclophilin inhibitor alisporivir prevents hepatitis C virus-mediated mitochondrial dysfunctionHepatology (Baltimore, Md.)May 1, 2012Quarato G, D'Aprile A, Gavillet B, Vuagniaux G, Moradpour D, Capitanio N, Piccoli C.

(15) DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5APloS oneOctober 27, 2010Coelmont L, Hanoulle X, Chatterji U, Berger C, Snoeck J, Bobardt M, Lim P, Vliegen I, Paeshuyse J, Vuagniaux G, et al.

(16) Predicting pesticide emissions and downwind concentrations using correlations with estimated vapor pressuresJournal of agricultural and food chemistryAugust 1, 2001Woodrow JE, Seiber JN, Dary C.

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Alisporivir from MedChemExpress

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Alisporivir from MedChemExpress

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