Description
ICAMs are members of the Ig superfamily of calcium-independent transmembrane glycoproteins. CD54 (ICAM-1) is a ligand for lymphocyte function-associated (LFA) and Mac-1 integrins and the major human rhinovirus receptor. The primary function of CD54 (ICAM-1) is to provide adhesion between endothelial cells and leukocytes after stress or injury. The human CD54 (ICAM-1) gene codes for a 505 amino acid transmembrane glycoprotein containing a 29 amino acid cytoplasmic domain, a 23 amino acid transmembrane domain, and a 453 amino acid extracellular domain. Recombinant human CD54 (ICAM-1) is a 49.5 kDa glycoprotein comprising the extracellular domain (453 amino acid residues) of CD54 (ICAM-1). Monomeric glycosylated CD54 (ICAM-1) migrates at an apparent molecular weight of approximately 72.0- 80.0 kDa by SDS-PAGE analysis under reducing conditions