Description
CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MHC (Major Histocompatibility Complex) Class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as HIV receptors, binding directly to the envelope protein gp120 on HIV. Thymocytes which are CD4 (+) and CD8 ( - ) produce factors such as IL-4, IL-5, IL-10 and IFN-gamma. Recombinant Human sCD4 produced in Baculovirus is a single, glycosylated polypeptide chain of 365 amino acids and a non-glycosylated molecular mass of 45,000 Dalton. As a result of glycosylation, the sCD4 migrates as a 46,000 Dalton protein on standard SDS-PAGE