Description
Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with beta-galactoside moieties. Galectin-2 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T- leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-2 produced in E. coli is a single, non-glycosylated polypeptide chain of 152 amino acids (1-132 a.a.) and a molecular mass of 16.8 kDa. It is fused to a 20 amino acid His-Tag at the N-terminus and purified by proprietary chromatographic techniques