Description
The 88-kDa Progranulin, also called proepithelin is a PC cell-derived growth factor. It is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. They are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Granulins are a variety of active, 6 kDa peptides named granulin A (epithelin 1), granulin B (epithelin 2), granulin C, etc. Both the peptides and intact progranulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.:Human recombinant Progranulin fused to FLAG at its C-terminus and produced in HEK cells is a single, glycosylated polypeptide chain of 593 amino acids having a molecular mass of 88 kDa. It is purified by standard chromatographic techniques