Description
The leukocyte-associated protein consists of two polypeptide chains with molecular weights of 95 and 170 kDa (936-1154 a.a.). It functions as a cell surface receptor for the C3bi complement fragment and belongs to a family of heterodimeric proteins (designated CD11) which share a common beta chain of 95 kDa with CD18. The alpha chain component of the leukocyte- associated antigen is expressed on granulocytes, monocytes and macrophages. CD11b belongs to the integrin alpha chain family