Description
Placenta growth factor (PlGF), a homodimeric glycoprotein that is homologous to vascular endothelial growth factor (VEGF), is mitogenic to endothelial cells and protects trophoblast from apoptosis. Alternative splicing of mature mRNA gives rise to three known isoforms of PlGF. PlGF is expressed by human trophoblast during normal pregnancy, however, it is not known which isoforms are produced. Recombinant human Placenta Growth Factor-2 (PIGF/PGF) produced in insect cells is a homodimeric, glycosylated polypeptide chain containing 2 x 152 amino acids and having a total molecular mass of 44 kDa