Description
A peptide antagonist of FPR2 (IC50 = 0.23 µM) and FPR3; inhibits increases in intracellular calcium and chemotaxis induced WKYMVm in RBL-2H3 cells expressing FPR2 and by F2L in isolated human monocytes at 10 µM; prevents Aβ42-induced production of superoxide in isolated human neutrophils at 10 µM; increases lung edema and BALF protein levels in the absence and presence ceftriaxone in a mouse model of acute lung injury induced by S. pneumoniae at 1 mg/kg