Human PDGF-BB Recombinant Protein PHG0041 from Thermo Fisher Scientific

Product Specs
ItemHuman PDGF-BB Recombinant Protein
CompanyThermo Fisher Scientific
Price Supplier Page View Company Product Page
Catalog NumberPHG0041
Regulatory StatusFor Research Use Only. Not for use in diagnostic procedures
Size100 µg
ApplicationsCELL CULTURE

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Thermo Fisher Scientific

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Waltham, MA 02451

United States

Phone: 800-678-5599

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Website: www.thermofisher.com

(1) Brain vascular stability relies on PAK2–cilia–PDGF-BB–HSPGs on basolateral side of endotheliumLife Sci AllianceJanuary 5, 2026Shubhangi Prabhudesai, Karthikeyan Thirugnanam, Xuehong Song, Hua Yang, Mariella Errede, Francesco Girolamo, Thomas Neumann, Andrea Marzullo, Sepand Bafti, Kayla Vanderhoef, et al.2022). Zebrafish injections Zebrafish protein injections were carried out with human recombinant PDGF-BB protein (PHG0045; Life Technologies) (1 ng/embryo), which was injected into entire clutches of one-cell-stage embryo

(2) Midkine promotes PDGF-BB-induced proliferation, migration, and glycolysis of airway smooth muscle cells via the PI3K Akt pathwayPhysiological reportsSeptember 1, 2025Xu Y, Li W, Shi J, Guo Y.were transfected with negative control siRNA (si‐NC) for 48 h, followed by treatment with PDGF‐BB (Cat#PHG0041, Gibco, Waltham, MA, USA) (20 ng/mL) for 24 h to induce proliferation and phenotypic changes. (3) Midkine

(3) CIAPIN1 promotes proliferation and migration of PDGF-BB-activated airway smooth muscle cells via the PI3K/AKT and JAK2/STAT3 signaling pathwaysPhysiological reportsMay 1, 2025Zhu L, Zhou J, Gu Y, Xu Y, Guo Y.provided crucial baseline data for the experiment, (2) model group (PDGF‐BB: 20 ng/mL) PDGF‐BB (cat no. PHG0041, Gibco, Waltham, MA, USA) treatment for 24 h, (3) silencing control group (PDGF‐BB + siNC), where cells

(4) Anandamide Inhibits Vascular Smooth Muscle Migration, Endothelial Adhesion Protein Expression and Monocyte Adhesion of Human Coronary Artery CellsCellsDecember 19, 2024Elane Blessing, Elisa Teichmann, Burkhard Hinzpenicillin-streptomycin, GibcoTM trypan blue solution (0.4%), GibcoTM trypsin-EDTA, PDGF-BB human (#PHG0041), Lipofectamine™ RNAiMAX (#13778075) transfection reagent and Opti-MEMTM I Reduced Serum Medium (#31985062)

(5) Estrogen receptors differentially modifies lamellipodial and focal adhesion dynamics in airway smooth muscle cell migrationMolecular and Cellular EndocrinologyJanuary 1, 2024Nilesh Sudhakar Ambhore, Premanand Balraj, Christina M. Pabelick, Y.S. Prakash, Venkatachalem Sathishobtained from Tocris (Minneapolis, MN). Human recombinant platelet-derived growth factor (PDGF-BB, Cat# PHG0046), protease and phosphatase inhibitor (PPI) cocktail (Cat# 78440), ERα monoclonal antibody (33, Cat#

(6) Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockoutThe FASEB JournalNovember 1, 2023Ying Bai, Liz Bentley, Chao Ma, Navaratnam Naveenan, James Cleak, Yixing Wu, Michelle M. Simon, Henrik Westerberg, Ramón Casero Cañas, Neil Horner, et al.either complete culture media or complete media supplemented with 20 ng/mL recombinant human PDGF-BB (PHG0044, Gibco, USA), 5 ng/mL mouse recombinant TGF-β1 (7666-MB, R&D® System, USA) or 10 μM cytochalasin D (C2618,

(7) Non-Psychoactive Phytocannabinoids Inhibit Inflammation-Related Changes of Human Coronary Artery Smooth Muscle and Endothelial CellsCellsSeptember 30, 2023Teichmann E, Blessing E, Hinz B.bought from Sigma-Aldrich (Taufkirchen, Germany). Platelet-derived growth factor (PDGF)-BB human (#PHG0041) was purchased from Thermo Fisher Scientific (Schwerte, Germany). AM251 (#71670), AM630 (#10006974),

(8) Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchymeNature communicationsJune 13, 2023Alber AB, Marquez HA, Ma L, Kwong G, Thapa BR, Villacorta-Martin C, Lindstrom-Vautrin J, Bawa P, Wang F, Luo Y, et al.smooth muscle differentiation medium36, consisting of cSFDM with 10 ng/ml rhPDGF-BB (Life Technologies, #PHG0046), 10 ng/mL rmTGF-β (R&D Systems, #7666-MB-005), and 10 ng/mL rhFGF2 (R&D Systems, #233-FB) for 4 days.

(9) A Soluble Platelet-Derived Growth Factor Receptor-β Originates via Pre-mRNA Splicing in the Healthy Brain and Is Upregulated during Hypoxia and AgingBiomoleculesApril 21, 2023Payne LB, Abdelazim H, Hoque M, Barnes A, Mironovova Z, Willi CE, Darden J, Houk C, Sedovy MW, Johnstone SR, et al.were treated with 50 ng/mL recombinant human platelet-derived growth factor-BB (PDGF-BB, 50ng/mL, #PHG0045, ThermoFisher, Waltham, MA, USA) for 24 h prior to harvest. Mouse embryonic stem cells (ESCs) harboring

(10) Hepatocyte SREBP signaling mediates clock communication within the liverJournal of Clinical InvestigationApril 17, 2023Dongyin Guan, Hosung Bae, Dishu Zhou, Ying Chen, Chunjie Jiang, Cam Mong La, Yang Xiao, Kun Zhu, Wenxiang Hu, Trang Minh Trinh, et al.(MilliporeSigma, SCC119) was treated with 20 ng/mL recombinant PDGF (Gibco, Thermo Fisher Scientific, PHG0045) for 24 hours, and the expression of its target gene Jund was determined by qPCR. Western blotting. An

(11) Engineering Nanofiber Scaffolds with Biomimetic Cues for Differentiation of Skin-Derived Neural Crest-like Stem Cells to Schwann CellsInternational journal of molecular sciencesSeptember 16, 2022Podder AK, Mohamed MA, Tseropoulos G, Nasiri B, Andreadis ST.their heparin-binding domain (HBD) domain. Heparin-binding growth factors such as PDGF-BB (Catalog #PHG0045, Gibco, Thermo-Fisher), FGF2 (Catalog #PHG0021, Gibco, Thermo-Fisher), and Heregulin/Neuregulin beta1/NRG1

(12) Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stabilityBiochemical pharmacologyAugust 1, 2022Thirugnanam K, Prabhudesai S, Van Why E, Pan A, Gupta A, Foreman K, Zennadi R, Rarick KR, Nauli SM, Palecek SP, et al.Recombinant proteins used in this study include human PDGF-BB recombinant protein (Thermo fisher Cat # PHG0045), and human VEGF-A165 recombinant protein (Thermo fisher Cat # PHC9394). Silencing RNAs (siRNA’s) used

(13) Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal CalcificationCellsMay 21, 2021Seime T, Akbulut AC, Liljeqvist ML, Siika A, Jin H, Winski G, van Gorp RH, Karlöf E, Lengquist M, Buckler AJ, et al.serum–starvation, cells were separately treated with a panel of cytokines and growth factors (PDGFB, #PHG0044, Gibco, 50 ng/mL; TGFβ1, #T7039, Sigma, 20 ng/mL; TNFα, PeproTech, Rocky Hill, NJ, USA, 20 ng/mL; IFNγ,

(14) Activation of Receptor Tyrosine Kinases Mediates Acquired Resistance to MEK Inhibition in Malignant Peripheral Nerve Sheath TumorsCancer ResearchFebruary 1, 2021Jiawan Wang, Kai Pollard, Ana Calizo, Christine A. Pratilasat Massachusetts General Hospital (Boston, MA). Recombinant human HGF (rhHGF, #PHG0324) and PDGF (#PHG0045) were purchased from Thermo Fisher Scientific. Doxycycline was from Sigma Aldrich; puromycin and hygromycin

(15) Vitamin K Epoxide Reductase Complex Subunit 1-Like 1 (VKORC1L1) Inhibition Induces a Proliferative and Pro-inflammatory Vascular Smooth Muscle Cell PhenotypeFrontiers in cardiovascular medicineJanuary 1, 2021Aksoy A, Al Zaidi M, Repges E, Becher MU, Müller C, Oldenburg J, Zimmer S, Nickenig G, Tiyerili V.(Sigma-Aldrich, Cat# T7765) or platelet-derived growth factor (PDGF, Thermo Fisher Scientific; Cat# PHG0044). Statistical Analysis Statistical analyses were performed using the software GraphPad Prism 9. Means

(16) Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertensionNature communicationsMarch 4, 2020Sindi HA, Russomanno G, Satta S, Abdul-Salam VB, Jo KB, Qazi-Chaudhry B, Ainscough AJ, Szulcek R, Jan Bogaard H, Morgan CC, et al.were defrosted, supplemented with 10 µM EdU, with or without 10 ng/mL PDGF (Thermo Fisher Scientific, PHG0044) and added to HPASMCs. EdU proliferation assay was performed, as previously described. HPAEC and ECFC

(17) Generation of a Purified iPSC-Derived Smooth Muscle-like Population for Cell Sheet EngineeringStem Cell ReportsSeptember 1, 2019George Kwong, Hector A. Marquez, Chian Yang, Joyce Y. Wong, Darrell N. Kottoncells in a well of a 6-well plate) in cSFDM supplemented with 10 ng/mL rhPDGF-BB (Life Technologies, #PHG0046), 10 ng/mL rmTGF-β (R&D Systems, #7666-MB-005), and 10 ng/mL rhFGF2 (R&D Systems, #233-FB). On day 13

(18) The GalNAc-T Activation (GALA) Pathway: Drivers and markersPLOS ONEMarch 19, 2019Joanne Chia, Felicia Tay, Frederic Bardgrowth factor EGF (#SRP3027) was purchased from Sigma aldrich. PDGF-BB Recombinant Human Protein (#PHG0046), Helix pomatia Lectin A (HPL) conjugated with 647-nm fluorophore (#L32454) and anti-GFP (#A11122) were

(19) Pirfenidone suppresses the abnormal activation of human Müller cells after platelet-derived growth factor-BB stimulationInternational journal of ophthalmologyJanuary 1, 2019Tao YJ, Chen Q, Wang L, Yang X, Cun Q, Yang WY, Zhong H.To establish the pathogenic model, the normal Müller cells were treated with 10 ng/mL PDGF-BB (GIBCO, USA, PHG0046) for 48h and then harvested for further experiments. The cells treated with PDGF-BB were named model

(20) Rab23 Regulates Radial Migration of Projection Neurons via N-cadherinCerebral CortexApril 1, 2018Catherine H H Hor, Eyleen L K GohStimulation Assay DIV 7 cortical neuron culture was incubated with 50 ng/mL of PDGF-BB (Thermo Scientific, #PHG0045) for 10 min at 37 °C. Total protein lysates were extracted immediately after the PDGF-BB stimulation.

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Human PDGF-BB Recombinant Protein from Thermo Fisher Scientific

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Human PDGF-BB Recombinant Protein from Thermo Fisher Scientific

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