Fig 1: Evaluation of preimplantation lineage module scores and their distribution across datasets(A) Schematic representation detailing the calculation of phenotype module scores and Kolmogorov-Smirnov distances to assess score distribution differences.(B) UMAP visualization highlighted by the normalized expression of the cell-type labels, EPI_ICM, PE, and TE module scores, from left to right. The top figure displays all datasets within the shared transcriptomic landscape, whereas bottom figures illustrate dataset-specific labels and module score expressions in the shared landscape.(C) Heatmap depicting the KSD for the EPI_ICM score among the datasets, annotated by module score distributions.(D) Analogous to (B), focusing on the module score for the PE.(E) Similar to (B–D), detailing the analysis for the TE module score. G, marker genes; M, phenotype module; DS/S, datasets/sample; CDF, cumulative distribution function. The boxplots presented show median ±0.25 quantiles (25th–75th percentile) with arms extending to ±0.40 quantile (10th–90th percentile), unless specifically described.