Description
OC43 is one of seven known coronaviruses to infect human, including HCoV-229E, HCoV-NL63, HCoV-HKU1, MERS-CoV, the original SARS-CoV1, and SARS-CoV-2 (Covid 19). Along with human alpha-coronavirus 229E and NL63, and beta-coronavirus HCoV OC43 and HCoV-HKU1 are responsible for the common cold. It has, like other beta-coronavirus, an additional shorter spike protein called hemagglutinin esterase (HE).
Human coronavirus OC43 (HCoV-OC43) is a member of the species beta-coronavirus with an enveloped, positive-sense, single-stranded RNA virus which enters its host cell by binding to the N-acetyl-9-O-acetylneuraminic acid receptor.
Recombinant human coronavirus OC43 nucleoprotein is full length protein except the predicted signal peptide of the first 30 amino acids, and a 6 x his tag at its C terminal. This protein has the following sequence and migrate at 50kDa