Description
Recombinant human PTPRA (174-802) was expressed in E Coli cells using an N-terminal GST tag. The gene accession number is NM_002836.
PTPRA (also known as LRP) is a member of the protein tyrosine phosphatase family and contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. PTPRA dephosphorylates SRC family kinases, potassium channels and NMDA receptors and exists as three alternatively spliced variants which encode two distinct isoforms (1). Absence of PTPRA compromises correct positioning of pyramidal neurons during development of mouse hippocampus (2)