Description
sRANKL Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain (158-316 a.a) having a molecular mass of 19kDa. The sRANKL is purified by proprietary chromatographic techniques.
Introduction: RANKL binds to tnfrsf11b/opg and to tnfrsf11a/rank. Osteoclast differentiation and activation factor. augments the ability of dendritic cells to stimulate naive t-cell proliferation. May be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. sRANKL may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy