Description
Recombinant human TPM3-PDGFRB, the fusion protein [TPM3 (1-258)-PDGFRB (528-end)], was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The TPM3 gene accession number is NM_152263 and, PDGFRB's one is NM_002609.
TPM3 is an actin-binding protein that mediates myosin-actin response to calcium ions in skeletal muscles. PDGFRB is a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. PDGFRB is located at chromosome 5q31-33, and has been reported to have at least 18 fusion partners. It was uncovered that the TPM3 gene at 1q21 as a PDGFRB partner in chronic eosinophilic leukemia (CEL)