Description
Recombinant human EPHB4 (I782S)(561-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_004444.
EPHB4 is a member of the EpHfamily of receptor tyrosine kinases which play a role in regulating cell adhesion and cell movement during embryonic development (1). Furthermore, because tissue disorganization and abnormal cell adhesion, movement, and survival characterize the more advanced stages of cancer, the inappropriate functioning of EpHreceptor could play a causal role in malignancy (2). EPHB4 is uniquely expressed in the vascular endothelial and endocardial cells and animal knockout studies with EPHB4 reveal a phenotype that is similar to Ephrin B2 gene knockdown. Furthermore, EPHB4 has been shown to be the major essential interaction partner of Ephrin B2 in angiogenesis