Description
IL-17RB, also known as Interleukin-17 receptor B, is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17A or IL17C. It has been shown to mediate the activation of NFkappaB and the production of IL8 induced by IL17E. It was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. Recombinant human IL-17RB, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques