Description
Introduction: Thrombospondin-4 (THBS4) is a member of the thrombospondin protein family. This family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. THBS4forms a pentamer and binds to heparin and calcium. Among them THBS4binds a variety of matrix proteins including Collagens I, II, III, V, Laminin?1, Matrilin?2 and Fibronectin. THBS4 is up?regulated in the spinal cord following peripheral nerve injury where it contributes to presynaptic hypersensitivity and hyperalgesia and is also up?regulated in muscle following denervation.
Description: THBS4 Mouse Recombinant produced in HEK293 Cells is a single, glycosylated polypeptide chain containing 943 amino acids (27-963a.a) and having a molecular mass of 104.3kDa.
THBS4 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques