Description
Recombinant SARS-CoV Spike Protein S1 (14-680) was expressed in CHO cells using a C-terminal human IgG1 Fc tag.
Overview: The severe acute respiratory syndrome related novel Corona virus (SARS-CoV) has caused the 2002-2003 SARS epidemic that broke out in southern China, which spread to other regions of Asia, Europe and North America (1). The spike glycoprotein (S) of Corona virus belongs to the type I transmembrane protein containing two subunits, S1 and S2 (2), which is also known to be the key component to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2). SARS-CoV can specifically recognize ACE2 through its receptor binding domain (RBD) of S1 to initiate viral infection in humans (3)