Description
Recombinant full-length Canis lupus NNMT was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The NNMT accession number is XM_546514.
Nicotinamide N-methyltransferase (NNMT) is expressed predominantly in the liver, and mediates the N-methylation of nicotinamide and other pyridines. The activity of NNMT is involved in drug and xenobiotic toxicity (1). NNMT has also been identified as serum tumor marker for colorectal cancer (2), as well as potential marker in urine-based diagnostic test for bladder cancer (3)