Description
Recombinant EBVgH, gL and gp42 proteins expressed andpurified from 293 cells. C-terminal 6xhis-tagged recombinant EBV gHprotein (aminoacid 1-344) (GenBank accession#: P03231)in complex with gL (aa 25-137) (GenBank accession#: CAD53428) and gp42 (aa 31-223) (GenBank accession#: YP_401672)
Introduction: Herpes viruses have an envelope andan outer lipid bilayer which contains up to twelve surface glycoproteins. For infectivity to be attained, the double stranded DNA genome of EBV must enter the host cell through means of fusion of its envelope with the cellular membrane or via endocytosis. Epstein–Barr virus (EBV)can infect both B cells and epithelial cells. The mechanisms for entering these two cells are different. The viral three-part glycoprotein complexes of gHgL/gp42 mediate B cell membrane fusion