Description
Recombinant HSV-1 glycoprotein D expressed andpurified from 293 cells. C-terminal 6xhis-tagged recombinant gD (HSV-1) (amino acid 27-310) (GenBank accession#: AAK19597)
Introduction: Glycoprotein D (gD) is a structural component of the herpes simplex virus (HSV) envelope which is essential for virus entry into host cells. Herpesviruses have an envelope andan outer lipid bilayer which contains twelve surface glycoproteins. For infectivity to be attained, the double stranded DNA genome of HSV must enter the host cell through means of fusion of its envelope with the cellular membrane or via endocytosis. Other viral glycoproteins involved in the process of viral cell entry include gC,gB,gD,gH, and gL, but only gC,gB,gD, and gH are required for the fusion of the HSV's envelope with the cellular membrane